A New Research Article Was Published

Ellen T. Chen and John T. Thornton, Speeding-up Screening of S1 SARS-CoV2 Inhibitors by Nanostructured Biomimetic ACE2 Sensors Based on a Superconductive Josephson Junction Toroidal Array Oscillating Effect, 2025, ECS Sens. Plus, 4, 025001. DOI 10.1149/2754-2726/adbe8c. Publication date: April 11, 2025 online.

Highlights

·         Developed a method for integrating a quantum superconductive oscillation effect, induced by a potential S1 SARS-CoV-2 inhibitor, which achieves a 99.992% blockade of S1 virus communication with a biomimetic angiotensin-converting enzyme 2 (ACE2) sensor over a wide range of virus concentration from 40 aM to 120 nM compared with an established virus inhibitor with a blockade of 99.998% under antibody-free and label-free condition for fast-screening potential pharmaceutical inhibitors at zero-applied potential by cyclic voltammetry (CV) method.

·            Developed a 3D nanocage structured biomimetic ACE2 membrane sensor with superconductive Josephson toroidal junction array (JTJA) enabled Friedel oscillation observed in atomic force microscopy (AFM) images, which laid a foundation toward applications of superconductive quantum oscillation when a suitable potential S1 virus inhibitor presents, it turned from a d-wave memristive state to a d-wave superconductive quantum state, promoting a phase-transmission to a high-frequency superconductive quantum oscillation at room temperature. This oscillation effect offers the advantage of being protein-protein interference-free and it not only blocks virus communication but also makes the virus unwillingly act as an insulator, which enables Cooper-pair across the primary insulator of zinc ions, and the secondary insulator virus. The system kept consistent superconductive oscillation as one unit over a wide concentration range. Herein the virus is no longer being toxic to the system. This oscillation effect has the advantage of being free from protein-protein interference. It not only blocks virus communication but also causes the virus to inadvertently act as an insulator. This property enables Cooper pairs to across the primary insulator of zinc ions and the secondary insulator provided by the virus. The system maintains a consistent superconductive oscillation as a single unit over a wide range of virus concentrations. In this context, the virus is no longer toxic to the system.

·         By employing a voltage method, the inhibitors restored 100% of the cells' reversible membrane potential within a clinically safe range, compared to only 50% restoration without the inhibitors using spiked human blood specimens.